8 RESULTS
COMMENT This is an interesting article. I do think it is one of a growing number of reports that factors associated with cognitive reserve (CR) may actually directly affect Alzheimer pathology. We also have a previous report (Lo et al., 2013) in which we looked ...
COMMENT I think that both the FDA guidance and the New York Times editorial are thoughtful responses to a difficult problem. We have to change the way we test drugs for AD if we want to move to trials in preclinical individuals, and the FDA guidance provides a ...
COMMENT I think this is consistent with a theme that is gradually emerging in the literature: ApoE has effects on the brain that are not simply related to its effect on the processing of Aβ. One always has to be concerned about the issue of multiple comparisons ...
COMMENT This is another very interesting paper from David Holtzman's lab, continuing a very interesting theme that suggests neural function (or dysfunction, in this case) affects Aβ deposition. Previous work (a nice paper by in Nature Neuroscience last year, ...
COMMENT This paper is very interesting, and another in a series by Brad Dickerson showing that his "cortical signature" set of regions of interest (ROIs) seems to be a pretty good biomarker for AD. I think in the aggregate, the work is impressive—he ...
COMMENT I was a member of the MCI committee and helped define the biomarker criteria in that draft document, so am biased in this sense. In light of some of the media coverage, a few points seem worth noting: 1. The criteria are designed to be multipurpose, that ...
COMMENT This paper takes the previous associations between brain function and β amyloid deposition a step further. These investigators have previously noted the interesting similarity between regions of β amyloid deposition and the default mode network. Using a ...
COMMENT It is difficult to understand why the results of the Rotterdam study and ours are different. The analyses were different, the measures of estrogen were different (in our study we did not measure levels, but only looked at estrogen replacement or not), and ...
