3 RESULTS
COMMENT Reading the two excellent papers from Genentech, I was quite impressed by their elegant approach to raise anti-BACE1 antibodies that reduce Aβ production in vivo in brain. They further engineered the anti-BACE1 antibody by coupling it with a low-affinity ...
COMMENT This paper reports increased levels of endogenous APP CTFβ as well as of Aβ in the hippocampus of X11L knockout mice. The researchers, headed by Toshi Suzuki of Hokkaido University, Sapporo, who has led APP research in relation to its cytoplasmic binding ...
COMMENT A number of mutations in presenilin (PS) 1, 2, or APP genes linked to familial AD (FAD) have been shown to increase the ratio of Aβ42/Aβ40 secreted from cells, or in the brains of transgenic mice overexpressing these mutant genes. As pointed out by ...
