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Michael Irizarry on Follow the Leader to Higher BACE Levels

COMMENT Elevated BACE at the mRNA, protein, and/or activity levels have been found in the Alzheimer's disease (AD) and aging brain. Clarifying the mechanism of BACE alterations in AD will contribute to identifying therapeutic targets. This rigorous study ...

Michael Irizarry on Target BACE: Better Than Ever?

COMMENT This elegant report further supports BACE1 as a rational therapeutic target for treating the cerebral amyloidosis of Alzheimer's disease (AD). Ohno and colleagues eliminated BACE1 function in a mouse model of AD by crossing Tg2576 mice—which ...

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