4 RESULTS
COMMENT “Allen Roses is my uncle” was sometimes the first thing I would tell Alzheimer’s researchers soon after I met them, almost like a disclosure of sorts, since the research community had strong opinions about him (and vice versa!). Over the course of my life ...
COMMENT The study by Fryer et al. answers fundamental questions regarding the role of LDL receptor (LDL-r) family members in the regulation of apolipoprotein E (ApoE) in the brain [1]. Characterizing lipid physiology in the brain is critical for understanding ...
COMMENT Elevated BACE at the mRNA, protein, and/or activity levels have been found in the Alzheimer's disease (AD) and aging brain. Clarifying the mechanism of BACE alterations in AD will contribute to identifying therapeutic targets. This rigorous study ...
COMMENT This elegant report further supports BACE1 as a rational therapeutic target for treating the cerebral amyloidosis of Alzheimer's disease (AD). Ohno and colleagues eliminated BACE1 function in a mouse model of AD by crossing Tg2576 mice—which ...
