11 RESULTS
COMMENT This approach is highly interesting- as it offers a radical way of suppressing the generation of Aβ and thereby reducing its associated neurotoxicity. The decrease of murine Aβ levels upon treatment of wild type mice was surprisingly robust even when the ...
COMMENT The new NIA-AA Framework for Alzheimer’s disease marks a big step forward in how we are looking at this disorder and will lead to better diagnostic principles. In addition, to base the diagnosis on pathobiology instead of clinical staging will help to ...
COMMENT The study by Chen et al. offers a possible explanation as to how Parkinson’s disease (PD)-related pathology may appear in the gut and subsequently spread to the CNS. By using two different animal models, rats and nematodes, the authors found that the ...
COMMENT This is an intriguing study. Already in 2007, Hui Zheng and colleagues (Kallhoff et al., 2007) showed that the lack of α-synuclein reduced plaque pathology and increased synaptophysin levels in Aβ transgenic mouse brains. Now, Bachhuber and colleagues ...
COMMENT This is an interesting paper, indicating a marked elevation in the levels of various truncated and multimeric α-synuclein species in the endoplasmic reticulum (ER) from α-synuclein transgenic mice and PD patients. In mice, aggregated α-synuclein species ...
COMMENT The work by Scott and colleagues is of great interest as it is trying to pinpoint the molecular details in the synaptic pathology caused by a modest transgenic overexpression of α-synuclein. The authors found that PK-resistant and abnormally ...
COMMENT Although the outcome maybe wasn’t as good as had been hoped for, the Phase 2 study on Bapineuzumab, a humanized anti-Aβ monoclonal antibody, provided novel perspectives to the field of immunotherapy against Alzheimer disease. The study enrolled 234 ...
COMMENT In this work from Dave Holtzman’s lab, the influence of the sleep-wake cycle on Aβ metabolism was explored. The investigators found that brain interstitial fluid levels of Aβ in transgenic mice fluctuated over a 24-hour period with lower levels during ...
COMMENT Several papers in 2009 have explored the physiological consequences of Aβ oligomers in Alzheimer disease. In this study from Brad Hyman’s lab, a novel method enabling precise quantification of small structures was adopted to study the presence of Aβ ...
COMMENT In this work, Susan Lindquist and colleagues from the Whitehead Institute reported a functional interaction between α-synuclein and the yeast ortholog of the Parkinson gene ATP13A2. Moreover, they showed that a knockdown of the corresponding ortholog in C ...
COMMENT It has been a good 10 years since the first disease-causing mutation in the α-synuclein gene (SNCA) was described in a family with autosomal-dominant Parkinson disease. However, in spite of a decade of intense research, only three pathogenic SNCA ...
