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Bradley Hyman on Widely Used Tau Seeding Assay Challenged

COMMENT There really never was a question that the conformational structure of the FRET-based bioreporter would be the same as tau aggregates in the brain–the former is short and has large fluorescent proteins attached, the latter is full-length and has ...

Bradley Hyman on Hyperactive Neurons and Amyloid, Side by Side

COMMENT This is a very interesting article. From our perspective, there are several important points: first, it highlights a plaque-specific alteration of neural function, but emphasizes that this occurs in the vicinity around plaques, suggesting a halo effect of ...

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