21 RESULTS
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COMMENT In this important study, Richetin et al. demonstrate that astrocytes in the hilus of the hippocampus dentate gyrus accumulate misfolded 3R-tau in Alzheimer’s disease (AD). Using an elegant lentiviral gene transfer approach in vivo (wild-type mice) and in ...
COMMENT There really never was a question that the conformational structure of the FRET-based bioreporter would be the same as tau aggregates in the brain–the former is short and has large fluorescent proteins attached, the latter is full-length and has ...
COMMENT Recent work has begun to challenge the long-held view that Aβ and tau sequentially contribute to Alzheimer’s disease (AD), and has provided evidence that both protein types may significantly interact with each other during the disease. This new study by ...
COMMENT Both the Holtzman lab and our lab explored the role of microglia in mediating tau-induced neurodegenerative phenotypes in mice. Here, Shi et al. present exciting results of marked neuroprotection in a tau model after microglial ablation. In a different ...
COMMENT I will always remember the time Bob Terry told me about his belief that serendipity plays a huge role in science, and how exciting it was to do the first EMs of human brain—something that he seemingly ended up doing almost by chance. Everything he saw was ...
COMMENT I think this is a really interesting advance. The biology underlying the specific hierarchical vulnerability patterns has been a mystery for years, and this work has the promise of providing a framework to understand it better. While clearly the patterns ...
COMMENT The ability to stimulate plasticity in the adult brain would provide a means to enable patient recovery from a variety of insults and conditions including stroke, amblyopia, and neurodegenerative disease. In this recent correspondence, Lunghi and Sale ...
COMMENT Yetman et al. report a straightforward experiment crossing Mayford’s Nop line S (which they obtained five years ago) with a reporter line. The initial line was selected from multiple lines because of its relative restriction to neurons of interest, ...
COMMENT This work, using a FRET-based assay that amplifies the signal from conformationally misfolded proteins, continues a strong series of studies from the Diamond lab examining the cell biology of misfolded tau and its ability to cross cell membranes. ...
COMMENT Several papers now have used multiphoton imaging to monitor plaques over time in AD transgenic models (Hefendehl et al., 2011; Burgold et al., 2010; Yan et al., 2009), following on the initial work we published in 2001 (Christie et al., 2001). Over the ...
COMMENT This is lovely technology with promise for future important biological studies and represents one of a series of technical improvements in multiphoton microscopy that allow deep imaging (e.g., with GRIN lenses) or use of awake, behaving animals. Along ...
COMMENT This is a very interesting paper from Allison Goate and coworkers, who push genotype-phenotype analyses to the next level—towards understanding how variations in biomarkers relate to risk of progression of disease. A specific allele of calcineurin B, one ...
COMMENT In response to concerns about the caspase inhibitor, we performed a control experiment, at the beginning of our study, to determine whether FLICA indicator inhibits caspase activation in vivo for an extended period. For this experiment, we used ...
COMMENT This is a very interesting article. From our perspective, there are several important points: first, it highlights a plaque-specific alteration of neural function, but emphasizes that this occurs in the vicinity around plaques, suggesting a halo effect of ...
COMMENT This is a fantastic study using an extraordinarily powerful technique to study human physiology and pathophysiology. While the implications for a "normal" function of Aβ are intriguing, it is still not completely clear whether the data reflect ...
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