Siegfried Hoyer on O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease.
COMMENT In their recent article, Liu et al provided clear evidence that abnormal hyperphospharylation of tau protein may be induced by decreased 0-GlcNAcylation subsequent to a deficient glucose metabolism in Alzheimer disease (AD) brain. Experimentally, the ...