60 RESULTS
COMMENT I found both of these papers fascinating. It is convincing that rocking in the young adult humans assessed increased NREM sleep, particularly stage 3, which is where the most slow-wave activity occurs. It also increased slow-wave oscillations and fast ...
COMMENT The new data clearly showed that the anti-Aβ antibody BAN2401 was able to significantly remove amyloid from brain, as quantified by amyloid-PET imaging, in very mildly to mildly impaired individuals with amyloid deposition. The highest dose administered, ...
COMMENT In Wang et al., the authors clearly demonstrate that there are several phenotypes seen in ApoE-4 versus ApoE3-expressing neurons derived from iPSC. They include increased tau phosphorylation, increased Aβ production, and a decrease in GABAergic neurons. ...
COMMENT I had the privilege to get know Ben very well over the last 10 years working with him in many settings. He was unique in many ways. He was obviously a superb scientist, but he was so incredibly imaginative and innovative in the way he approached things. ...
COMMENT In this work, Iaccarino et al. find that specific manipulation of brain gamma activity rapidly over an hour lowers Aβ40 and 42 levels as well as affects microglial gene expression in such a way as to make them more phagocytic. Over time, increasing gamma ...
COMMENT This work from the Herz lab presents an interesting set of findings. The mice they generated express ApoE in the periphery but not in the brain. The main finding is that there is a decrease in the synaptic marker synaptophysin in the neocortex in both ...
COMMENT I’m not an expert on the mathematical modeling done here. While it’s clear that vascular abnormalities can contribute to cognitive decline, I am very concerned about the conclusion drawn from this data, namely that vascular dysregulation is the earliest ...
COMMENT I think this is a very important set of findings on NfL. Certainly the changes seen in the animal models of α-synuclein, tau, and Aβ are much more prominent than in humans (probably because of marked overexpression of the transgenes). However, this ...
COMMENT The NIH 2016 budget that increases funding for research related to Alzheimer’s disease is both needed and welcomed. All of us dealing with the disease, patients, families affected, and researchers, should thank our governmental representatives. While a ...
COMMENT There is strong evidence that the LDL receptor (LDLR) regulates apoE levels in the brain. Increasing LDLR decreases apoE and Aβ and decreasing LDLR has the opposite effect. These effects may occur via apoE’s ability to modulate Aβ levels, or potentially, ...
COMMENT Regarding Jansen et al., this paper estimates the percentage of people who are amyloid positive from a cross-sectional meta-analysis of published studies in cognitively normal people, people with subjective cognitive impairment, and people with mild ...
COMMENT The results reported are interesting and certainly the use of iPSCs has a lot of promise in uncovering mechanisms. However, I think the findings reported are difficult to interpret in regard to any relationship they do or don’t have with fAD. A technical ...
COMMENT It is clear from genetics, biochemistry, and both animal studies and human studies that Aβ and tau are both important in causing Alzheimer’s disease. There is also a lot of suggestive data that the accumulation of Aβ in the brain somehow drives the ...
COMMENT This paper by Ooms and colleagues studies the effect of sleep deprivation in humans on cerebrospinal fluid (CSF) Aβ40, Aβ42, tau, p-tau, and total protein in middle-aged individuals with lumbar catheters. It is found that CSF Aβ42 decreased in those who ...
COMMENT We agree with the comment by Irene Griswold-Prenner that given the results by both Pooler et al. and Yamada et al., it will be very interesting to determine whether secreted forms of tau are linked in any way to hyperexcitability and possibly seizures. ...
