COMMENT The evaluation of cognitive tests for their predictive abilities requires, and seems to routinely receive, close attention to the testing context. Subjects are all familiar enough with the computing device to rule out computer sophistication effects, espe
COMMENT Much like the research upon exercise and changes in cognitive ability, the at-home testing in research is extremely different from the at-home testing done without research supervision. The presence of a spouse during testing invalidates many, if not most
COMMENT It is probably too elementary a consideration, but the true blindness of a live neuropsychology technician to whether or not a subject is in active versus placebo status might be revealing. Just asking technicians to guess at the end of testing whether or
Emory Hill on Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume.
COMMENT Testing over 7,000 subjects (normal, mildly impaired, and demented), Scanlan and Laboff examined the relationships between three subjective patient questions concerning mental clarity, concentration, and memory, against objective memory and executive func
COMMENT “Clinicians … have to figure out how to communicate the potential risks and benefits to patients and their families, and how long to keep patients on the drug. Biogen’s post-market study may answer these questions.” Is that what patients’ families will be
COMMENT comments report that one factor limiting clinical relevance is doctor time, e.g., “Primary care physicians
COMMENT “…. [F]urther testing will need …. to show that knowing one’s genetic AD risk has a health benefit. If a person learns they are at a high genetic risk for AD, this could motivate them to adopt a healthier lifestyle to offset that risk.” In my view, knowin
COMMENT There are several contextual factors which may influence the results of exercise studies. The studies with the most positive results are designed and performed under very unusual circumstances by extreme exercise enthusiasts, without concern for the imple
COMMENT Dr. Rentz found that 62 percent of her "cognitively healthy, highly educated participants with an average age of 72" completed all tests successfully at home and that "scores from home and the clinic matched as well, with a correlation of 0
COMMENT Aside from the obvious conflict-of-interest issues involved with selecting commercial computerized tests, the use of tablet hardware is indicative of a failure to adequately consider usability. At face value, sending people home with nifty tablets may see
COMMENT appears that the AD8 is a snapshot that requires a high-quality informant. Comment? emory.hill
COMMENT We see people who are very interested in participating in clinical trials, but they want to get into the most promising active treatment trials, not something like a prevention via exercise study. They are asking for the most promising trials. Do we dare
Emory Hill on The relationships between television viewing in midlife and the development of Alzheimer's disease in a case-control study.
COMMENT This correlation approach is mostly harmless, but the focus upon intellectual stimulation for purposes of prevention may have some long-term negative consequences. Not only is it somewhat misleading (the significance, based on big samples, having little i