Jochen Herms on Peering Inside Stubby and Mushroom Dendritic Spines

COMMENT This is indeed an interesting and well-done study. From an Alzheimer’s disease perspective, it is interesting that APP is observed in spines in cultured neurons; this supports the work of my group 15 years back (Priller et al., 2006).  Tau on the other ...

Jochen Herms on Biogen/Eisai Halt Phase 3 Aducanumab Trials

COMMENT I like the important point Todd Golde stresses that it is not yet proven that a reduction in amyloid ligand PET signal following a treatment equates to a reduction of amyloid in the brain. Using in vivo 2-Photon imaging in a preclinical amyloid model (Tg ...

Jochen Herms on Merck Pulls Plug on Phase 2/3 BACE Inhibitor Trial

COMMENT One should not forget that certain side effects of drugs that interfere with APP cleavage, like BACE inhibitors, affect synaptic plasticity and cognition in mice (Filser et al., 2015; Zhu et al., 2016). Of course we do not know if this holds true for ...

Jochen Herms on Alzheimer’s Disease: In the Eye of the Patient?

COMMENT We tried really hard to find any fibrillar Aβ plaques in the retina, both in humans and in various transgenic AD mouse models, but we failed to see what Koronyo et al. 2011 and 2012 had described. In our hands there is no fibrillar Aβ in the retina—which ...

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