Robert Hermann on An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.
COMMENT It is fascinating that knocking out Scyl1 selectively in neurons precipitated TDP-43 and ubiquilin 2 neuropathology, suggesting Scyl1 is acting upstream. This could be an important new model of motor neuron disease with comprehensive neuropathology ...