10 RESULTS
COMMENT This paper by Park and colleagues reports novel findings showing that N,N'-Diacetyl-p-phenylenediamine (DAPPD) reduces Aβ plaque burden along with micro- and astroglial reactivity in APP/PS1 transgenic mice. DAPPD treatment decreased inflammatory ...
COMMENT Wendeln and colleagues present an intriguing study that provides evidence for an innate immune memory in the brain. The expansion of the trained-immunity concept from the periphery to long-lived innate immune cells in the brain is a very promising step ...
COMMENT Neuroinflammatory mechanisms have emerged as an important feature and pathogenic event in Alzheimer’s disease. Recently, mutations in TREM2 have been identified as risk factors for the development of the sporadic type of this neurodegenerative disease. In ...
COMMENT Genetic variants in TREM2 have been found to increase the risk of developing Alzheimer´s disease. This paper by Ullrich and colleagues aims to identify molecular mechanisms underlying this risk. Previously, TREM2 expression has been reported in microglia, ...
COMMENT Chronic neuroinflammation is a common feature of several degenerative disorders of the central nervous system, including amyotrophic lateral sclerosis, Parkinson´s disease, and Alzheimer´s disease. It is widely assumed that the sustained presence of ...
COMMENT Zhang and colleagues conducted experiments to prove a connection among hypothalamic function, innate immune activation, and systemic aging. In their experiments, they assessed systemic aging by overall lifespan, muscle endurance, muscle size, bone mass, ...
COMMENT Microglial Cytokines Light the Fire—Interleukin 12-, Interleukin 23-Mediated Inflammation May Act as Driving Force Behind Disease Progression The paper by vom Berg and colleagues further strengthens the hypothesis that innate immune reactions may strongly ...
COMMENT Triggering receptor expressed on myeloid cells 2 (TREM2) represents a surface receptor without its own intracellular signaling motif. It therefore depends on the adaptor protein 12 (DAP12) for the initiation of signaling cascades. TREM2 has been primarily ...
COMMENT This is a highly interesting paper that sheds further light on the fate of the noradrenergic system during the course of Alzheimer's disease. Central noradrenergic neurons, located in the locus ceruleus (LC), degenerate early in AD, and subsequently, ...
COMMENT This is an important and well-conducted study that may shed some light on the mechanisms that underlie the degeneration of the locus ceruleus (LC) in the course of Alzheimer disease (AD). LC degeneration is a very early and substantial feature of AD, as ...
