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Rita Guerreiro, John Hardy on γ-Secretase Revealed in Atomic Glory

COMMENT This study by Bai and colleagues resolves the γ-secretase structure to an atomic level (resolution of 3.4Ǻ). This type of detail allows the authors to map and analyze some of the reported PSEN1 disease-associated mutations and to start to develop clearer ...

Rita Guerreiro on Does Progranulin Play Both Sides in AD and FTD?

COMMENT These are very interesting data, adding to the many cases of potential pleiotropy that we are starting to see more often by applying next-generation sequencing to the study of neurodegenerative diseases. Before the availability of these technologies, ...

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