Lea T. Grinberg on A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP.
COMMENT In frontotemporal dementia, tau and TDP43 rarely appear together. People with #FTLD-TDP and TMEM106B polymorphism A/A have an odds ratio of 13.9 (crude) or 31.3 (multivariate) to develop a distinct 4R tauopathy. We investigated 90 FTLD-TDP cases—all types ...