8 RESULTS
COMMENT The intriguing cases described by the authors make a strong case for exposure to cadaveric dural material as a cause of CAA later in life. It’s reasonable to think this was due to direct β-amyloid seeding, but dura is not thought to contain large amounts ...
COMMENT The analysis raises interesting questions about possible links between neurosurgical procedures and CAA, though the numbers are too small to draw strong conclusions. The small numbers also make it hard to disentangle possible mechanisms, including ...
COMMENT This recent analysis by Ringman and colleagues at the UCLA Alzheimer’s Disease Research Center teases out the clinical and pathological features conferred by advanced cerebral amyloid angiopathy (CAA) in the setting of Alzheimer’s disease (AD). The ...
COMMENT The role of amyloid precursor protein (APP) in normal and pathological contexts remains elusive. Although its degradation products are the focus of intense research in the Alzheimer disease field, APP itself has also earned the nickname “the All-Purpose ...
COMMENT Abnormalities of the white matter are a universal component of aging. These white matter changes appear as hyperintensities on T2-weighted MRI sequences or as alterations of anisotropy, diffusivity, or magnetization transfer on more sensitive MRI ...
COMMENT This very nice study confirms the finding of Matthias Jucker and colleagues [1] that anti-Aβ antibody treatment can provoke CAA-related hemorrhage, in particular, antibodies that bind to deposited rather than soluble Aβ. The mechanism remains unclear; a ...
COMMENT The beautiful series of papers by Jucker and colleagues begin to paint a picture of how cerebrovascular amyloid deposition (or CAA) might occur: 1. Neuronally produced Aβ peptide appears to have the opportunity to deposit in the brain parenchyma as ...
COMMENT The effects of unfractionated (Neurobiol Aging 2002;23:531) and now fractionated heparins on Aß bioactivity (in vitro) and deposition (in vivo) are clearly intriguing, though it remains unclear how to tie these in-vitro and in- vivo findings together. The ...
