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Caroline Graff on Looking outside the Brain for Early Signs of AD

COMMENT Reply to comment by Andrei Yakovlev Though most of the comments will be answered by reading our supplemental data, we are going to provide brief answers to each comment as follows. “In this study, it is unclear how the results of clustering were used to ...

Caroline Graff on Looking outside the Brain for Early Signs of AD

COMMENT Reply to comment by Martin Ingelsson and Lars Lannfelt The first comment suggests that we have misunderstood the investigations made by Dr. Lannfelt on Aβ metabolism of the APParc mutation. “In the original publication (1) we describe low Aβ levels in ...

Caroline Graff on Looking outside the Brain for Early Signs of AD

COMMENT Reply to comment by Paul Coleman We expect that most of the comments would be solved by reading our paper and supplemental data posted in the ARF website carefully. The supplemental data were submitted to PNAS together with our paper manuscript, but ...

Caroline Graff on Looking outside the Brain for Early Signs of AD

COMMENT Reply to comment by Eric Blalock and Philip Landfield Regarding our choice of statistics to select differentially expressed genes, we have shown the formula used to calculate the CV values, and explained the way of thinking for the CV criterion, in the ...

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