46 RESULTS
COMMENT This is impressive work providing exciting new tools (a large library of isogenic APP and PS1 mutant iPSCs) to explore AD pathogenesis. They describe that both APP and PS1 mutant iPSCs have remarkably overlapping alterations in gene and protein ...
COMMENT If Winton et al. had reported on accumulation of APP in the triple transgenic there would not have been such a reaction. But the paper and the Alzforum webinar questioned the whole area of intraneuronal Aβ. Many in the field thought this was going too far ...
COMMENT A better understanding of axon versus dendrite APP and Aβ is important. DeBoer and colleagues show that APP is significantly more present at the surface of the plasma membrane of axons while it is more in the inside of dendrites. Using constructs to ...
COMMENT This is a very nice study using high-level microscopy to provide evidence for BACE1 and APP converging in dendritic endosomes of cultured neurons by live cell imaging following synaptic activation. It is less clear what this work means for Alzheimer’s ...
COMMENT This is a wonderful study by Dolev et al. that underscores why we need more experts in synapse biology to turn their attention to AD. In a remarkable paper, they show that the Aβ40/42 ratio depends on temporal spike bursting and synaptic facilitation. ...
COMMENT I'd like to clarify and extend my quoted comments about the interesting talk by Charlie Glabe at the AD/PD meeting. I was mainly referring to his new images of nuclear aggregates. Charlie did also show very nice new images of plaques appearing to ...
COMMENT Lauritzen et al. provide important new insights into age-related changes in APP fragments within neurons of the triple transgenic mouse. They show interesting early and age-related elevations in APP C-terminal fragments (CTFs), but not full-length APP, in ...
COMMENT Beker and colleagues contribute to the important question of what circuitry and cell types are particularly vulnerable in AD transgenic models of β amyloidosis. While we and others examined the barrel cortex in AD transgenic mouse models deprived of ...
COMMENT This is a very interesting study from a leading cell biology lab that tries to define the site of Aβ generation. Their approach of knocking down different components of trafficking steps in endosome and Golgi pathways is very nice. The authors provide ...
COMMENT This is a very interesting report showing that treatment with the antiepileptic levetiracetam improves both the task-specific hyperactivity in the DG/CA3 hippocampal circuit seen by fMRI in patients with amnestic MCI and also the cognitive task that ...
COMMENT This is a very interesting paper, carefully studying levels of secreted Aβ peptides with time in culture in wild-type neurons and noting a marked elevation of Aβ42 secretion between 21 and 28 days in vitro (DIV). The authors go on to define a mechanistic ...
COMMENT This paper by Watanabe and colleagues is of considerable interest; it provides evidence that Aβ precursor protein (APP) is ubiquitinated and that FBL2, a component of the SCF E3 ubiquitin ligase complex, is important in regulating APP trafficking, ...
COMMENT As highlighted in the news story, Abramowski and colleagues chose a risky approach in generating mice directly expressing Aβ40 or 42, thereby likely precluding the normal trafficking and localization of Aβ. While we have shied away from studying Aβ ...
COMMENT The use of human induced pluripotent stem (iPS) and induced neuronal (iN) cells is clearly a major step forward compared to standard clonal cell lines, and also to our own mainstay system, cultured primary AD transgenic neurons. However, the results with ...
COMMENT This article well summarizes a current consensus that has been emerging in the field based primarily on clinical trial failures. We need to be cautious, since it is not clear whether these treatments would work even if started early. Nevertheless, for ...
