5 RESULTS
COMMENT The biomarker effects in the gantenerumab arm are highly promising. In particular the robust effect on CSF measures of tau is a key point as the OLE moves forward. As a field we still do not understand the relationship between CSF measures of tau and the ...
COMMENT Due to the known nature of their mutations, autosomal-dominant cohorts are powerful models to understand Alzheimer's pathobiology. Any time an ADAD carrier significantly deviates from their expected trajectory, there is the possibility to gain ...
COMMENT Before we can say what utility NfL may have, we need to understand how levels of NfL discriminate between diseases states in a cross-sectional, one-off manner, as well as how it behaves over time. Understanding such a longitudinal change is critical for ...
COMMENT This study further highlights the growing interest in the field on how sleep is related to the regulation of Aβ levels in the brain. This is an important emerging area in the field that deserves greater exploration as sleep disturbances are well ...
COMMENT In general, I think tau imaging data is very promising, but there is a lot we have to learn. Increased Aβ pathology can occur decades before the onset of dementia, while elevations in tau pathology are thought to occur nearer to the onset of cognitive ...
