8 RESULTS
COMMENT I think the most important take-home message from these papers is that each finds evidence that the TREM2 locus is a risk factor for AD and AD-related traits. It would not be surprising for the odds ratio to be slightly lower than reported in the original ...
COMMENT There is a three-generation history of LOAD in the family reported in this study. Only the proband's DNA was sequenced, and as a result there is no evidence of segregation of disease with the mutation. However, this mutation has been reported in an ...
COMMENT This is a very interesting paper that is totally consistent with the Aβ hypothesis. The observation that duplication of APP causes early onset AD and CAA is consistent with the observations in Down syndrome (DS) and confirms that AD pathology in DS is due ...
COMMENT "Interesting paper showing an association between risk for AD and a polymorphism in the promoter of PS1. The risk genotype is also associated with increased Ab load in the brain. These observations are consistent with the hypothesis that increased ...
COMMENT This paper reports that the 234 bp allele of D10S1423 in conjunction with APOE4 is a strong predictor of AD. However, this is based upon only 18 incident cases of AD, thus more data is required to see if this holds up in larger samples. The marker is on ...
COMMENT More data suggesting that APOE4 does not have a major impact on risk for ad among people of African origin goate 0 ...
COMMENT Interesting paper highlighting differences in relative risk for ad associated with apoe4 genotype in different ethnic populations. Suggests that Hispanic or African a American populations might be a good place to start looking for other genetic risk ...
COMMENT Potential new risk factor for AD. goate 0 ...
