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Alison Goate on Fall Flurry of Letters Kicks Up Dust Around TREM2

COMMENT I think the most important take-home message from these papers is that each finds evidence that the TREM2 locus is a risk factor for AD and AD-related traits. It would not be surprising for the odds ratio to be slightly lower than reported in the original ...

Alison Goate on APP Double Dose Causes Early Onset AD

COMMENT This is a very interesting paper that is totally consistent with the Aβ hypothesis. The observation that duplication of APP causes early onset AD and CAA is consistent with the observations in Down syndrome (DS) and confirms that AD pathology in DS is due ...

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