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Charles Glabe on Enhancing Aβ Fibrillization Boosts Mouse Memory

COMMENT Alzheimer scientists have long known that amyloid plaques are not always associated with cognitive dysfunction. Indeed, some cognitively normal individuals have impressive numbers of insoluble amyloid plaques. Recent studies have shifted the focus to ...

Charles Glabe on Salzburg: Aβ’s N-terminal Shenanigans

COMMENT It is quite likely that amino-terminal deletions could also have an impact on the aggregation of Aβ. Christian Pike and Carl Cotman showed that amino-terminally truncated peptides aggregate faster than the corresponding full-length peptides. In addition, ...

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