15 RESULTS
COMMENT Despite the deep political divide within the country, the proposed 2019 fiscal year budget that passed in the Senate $2.3 billion dollars earmarked for Alzheimer’s disease research, effectively surpassing the 2018 fiscal year AD research budget by $425 ...
COMMENT This report of differential expression of exon-coding sequences (CDS) and 3′ UTR sequences in neurons and other cellular sources provides interesting information regarding potential regulation of cell-specific expression of individual transcripts and ...
COMMENT This case report study of the first Pittsburgh Compound B (PIB) positron emission tomography patient with Alzheimer’s disease (AD) by Kadir et al. provides extensive descriptive information regarding the neuropathological changes found in the brain of a ...
COMMENT I am deeply saddened by the untimely passing of Anne. She was a friend and collaborator, with a calm and caring demeanor and a great sense of humor. Anne was tremendously generous with her resources, always willing to share reagents and experimental data ...
COMMENT This paper is a jarring wake-up call to all Alzheimer disease investigators that placed all their research marbles in the amyloid hypothesis basket, as the clinical pathological findings suggest serious rethinking of the Aβ42 vaccination approach. Based ...
COMMENT This microarray-based study is quite provocative. This research group employed findings gleaned from earlier positron emission tomography (PET) and cerebral metabolic rate for glucose (CMRgl) studies in vulnerable regions of cerebral cortex and ...
COMMENT This paper by C. S. Lobsiger et al. is an experimental and conceptual tour de force. It combines laser capture microdissection (LCM) with Affymetrix oligonucleotide array analysis in superoxide dismutase 1 (SOD1) active versus inactive mutant rodent ...
COMMENT The technical and conceptual tour de force by J. Lim et al. illustrates some of the potential of combining high-throughput genomic and proteomic technologies with rational study design to expand the ever-growing list of disease-related candidate genes for ...
COMMENT The report by Tuszynski et al. is a fascinating study on many levels. First, the ability to deliver ex vivo nerve growth factor (NGF) via autologous fibroblasts genetically modified to express NGF for greater than 18 months into the nucleus basalis of ...
COMMENT In a recent technological advance published in the journal Science by Z.E. Perlman et al., the group provides convincing evidence of the use of high-throughput cytological profiling by automated microscopy. This system is essentially a combination of ...
COMMENT In the provocative report by Chen et al., oligonucleotide array analysis was performed using whole brain from P301L-transgenic mice as an input source of RNA. P301L mice express the longest human brain tau isoform, i.e., "big tau," with a ...
COMMENT The comprehensive report by Eric Blalock et al. correlates gene expression levels garnered from cDNA microarray analysis of Alzheimer’s disease hippocampus with cognitive scores on the Mini Mental Status Examination (MMSE) and neurofibrillary tangle (NFT) ...
COMMENT This compelling report provides cDNA microarray and RT-PCR evidence that a premature aging disorder, Werner syndrome (WS), closely resembles the expression profile of normal aging in a cultured cell line. WS is an autosomal recessive disorder of premature ...
COMMENT This convincing report provides integrated DNA, RNA, and protein data that is used for disease gene discovery in a rare form of a mitochondrial disorder named Leigh syndrome, an autosomal recessive cytochrome c deficiency. Specifically, the authors ...
COMMENT A compelling report by Cavallaro et al. demonstrates expression level changes within the hippocampus of rats using a conventional spatial learning task combined with Affymetrix U34 rat neurobiology gene chips. This group has a distinguished track record ...
