Florent Ginhoux on Janus-Faced PLCγ2? Alzheimer’s Risk Protein Toggles TREM2 and TLR Pathways

COMMENT This is a very interesting study. It linked TREM2 and PLCG2 signaling pathways in IPSC-derived macrophages/microglial cells to get insights into the mechanisms underlying the deleterious effect of TREM mutations and the protective effect of the PLCG2 ...

Florent Ginhoux on In Human Neurons, ApoE4 Promotes Aβ Production and Tau Phosphorylation

COMMENT These two complementary papers provide new insight on the mechanisms by which APOE4 could drive Alzheimer’s disease. Both studies used CRISPR/Cas9 and iPSCs to examine APOE4 effects on human brain cell types. In Lin et al., a striking observation is that ...

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Florent Ginhoux on Janus-Faced PLCγ2? Alzheimer’s Risk Protein Toggles TREM2 and TLR Pathways

Florent Ginhoux on In Human Neurons, ApoE4 Promotes Aβ Production and Tau Phosphorylation

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