5 RESULTS
COMMENT This is a great study and another proof of concept that human IPSC-derived culture/organoid systems, although not perfect since not recapitulating fully what is happening in vivo, are providing better models of human physiology and will be useful to gain ...
COMMENT Mindblowing technology! It will answer lot of questions and open new directions. At this stage this is still an “in vitro” approach, hence restricted to cell culture. However, it could be used in iPSC cell lines that researchers can direct to become ...
COMMENT This study shows that a small population of genes implicated in microglial activation, such as APOE, CST3, SPP1, and CD74, is depleted in “nuclei” versus “whole cell” single-cell RNA sequencing technologies. Importantly, these genes are part of the ...
COMMENT This is a very interesting study. It linked TREM2 and PLCG2 signaling pathways in IPSC-derived macrophages/microglial cells to get insights into the mechanisms underlying the deleterious effect of TREM mutations and the protective effect of the PLCG2 ...
COMMENT These two complementary papers provide new insight on the mechanisms by which APOE4 could drive Alzheimer’s disease. Both studies used CRISPR/Cas9 and iPSCs to examine APOE4 effects on human brain cell types. In Lin et al., a striking observation is that ...
