Florent Ginhoux on In Human Neurons, ApoE4 Promotes Aβ Production and Tau Phosphorylation
COMMENT These two complementary papers provide new insight on the mechanisms by which APOE4 could drive Alzheimer’s disease. Both studies used CRISPR/Cas9 and iPSCs to examine APOE4 effects on human brain cell types. In Lin et al., a striking observation is that ...