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Gary Gibson on Calcium Disruptions Wreak Synaptic Havoc

COMMENT Changes in calcium dynamics in cells from patients who have or will get Alzheimer’s disease have been reported for about 30 years (i.e., it is a trait-dependent, not state-dependent, marker). Considerable data at many levels (cell signaling, ...

Gary Gibson on Calcium in AD Pathogenesis

COMMENT Using the exact techniques that we used in the Ito studies to look at ER calcium in fibroblasts bearing presenilin mutations, we also examined ER calcium in lines bearing the APP670/671 lines. (No presenilin mutation; single APP mutation; Gibson et al., ...

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