8 RESULTS
COMMENT In a paper in the Journal of Alzheimer's Disease, we demonstrate that the oxysterol 27-hydroxycholesterol reduces leptin levels and increases levels of both Aβ and phosphorylated tau in organotypic slices from adult rabbit hippocampus. Interestingly, ...
COMMENT Whether accumulation of Aβ peptide, hyperphosphorylation of tau, or cell death is generated first in Alzheimer disease, and whether any of these are related, is still a matter of debate. Transgenic mice demonstrating an increased burden of Aβ deposits do ...
COMMENT In a recent review paper (Ghribi, 2006), we have addressed the role of ER in Alzheimer disease and discussed data supporting dysfunction of the ER as an early event leading to Aβ accumulation in familial AD. We have also discussed the possible role of ...
COMMENT Kang and co-workers examined the effect of PS1 and PS2 deficiency on PI3/Akt and ERK pathways, highlighting the importance of upstream cell-surface receptors in PS1- and PS2-mediated Akt and ERK signaling. The authors demonstrate that the loss of PS1 and ...
COMMENT ERK activation has been associated with the regulation of three major features of relevance to Alzheimer’s disease; these are hyperphosphorylation of tau (p-tau); memory and learning processes; and neurodegeneration. MEK1 is the upstream activator of ERK, ...
COMMENT The findings by Emamian and colleagues provide advances in our understanding of the mechanisms underlying the pathophysiology of schizophrenia. However, many questions remain to be addressed: 1. How does an alteration in AKT1/GSK3β signaling contribute to ...
COMMENT ER disturbance may result from protein misfolding or from perturbation in the ER calcium homeostasis. Both events can lead to the activation of one or more of the ER stress sensors, ATF6, PERK and IRE1. This cascade of events activates gadd 153 and ...
COMMENT We were the first to show that lithium fully prevents the activation of GSK-3 alpha in vivo. Indeed, we demonstrated that 7 mM lithium in drinking water prevented Abeta-induced translocation of GSK-3 alpha and beta into the nucleus in rabbit brain. This ...
