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Sam Gandy on Overactive Kinase May Drive Aβ to Depress Synapses

COMMENT In 1990, a series of independent papers converged to implicate a role for protein kinase C (PKC) in AD. Eliezer Masliah and Greg Cole, working in Tsunao Saitoh’s lab, discovered deficiencies in PKC activity in AD brain and fibroblasts (Masliah et al., ...

Sam Gandy on Could Bolstering the Retromer Thwart Alzheimer’s?

COMMENT My reaction is that the new pro-retromer drug is brilliant and essential, and at the very least, we have a terrific new tool for cell biology at the bench. In contemplating its use in treating or preventing AD, there are some caveats that tend to keep me ...

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