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Douglas Galasko on Remember: BACE2 Is in the Brain, Too

COMMENT I read this paper with interest. There are many substrates besides VCAM1 that might be altered as a result of BACE-2 inhibition, with potentially unknown effects on the brain. The magnitude of alteration was clearly higher in the presence of TNF-α, which ...

Douglas Galasko on Closing in on a Blood Test for Alzheimer’s?

COMMENT This plasma assay used IP-MS methodology, with standardization of plasma levels of Aβ42, 40, and a novel peptide by inclusion of Aβ38. The assay methods are well described, and the CV’s for the various plasma measures were low (around 5 percent). There ...

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