20 RESULTS
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COMMENT I read this paper with interest. There are many substrates besides VCAM1 that might be altered as a result of BACE-2 inhibition, with potentially unknown effects on the brain. The magnitude of alteration was clearly higher in the presence of TNF-α, which ...
COMMENT This plasma assay used IP-MS methodology, with standardization of plasma levels of Aβ42, 40, and a novel peptide by inclusion of Aβ38. The assay methods are well described, and the CV’s for the various plasma measures were low (around 5 percent). There ...
COMMENT The study of NfL in autosomal-dominant AD (ADAD) provides exciting preliminary evidence supporting this as a progression marker. The effect size was much more impressive in symptomatic patients than in preclinical carriers, and it will be interesting to ...
COMMENT Neurogranin appears to be an interesting and novel marker that appears to reflect post-synaptic damage. There are multiple proteolytically cleaved forms of neurogranin in CSF; this is reminiscent of tau, with which neurogranin correlates. It is possible ...
COMMENT Futility analysis has the potential to save unnecessary cost and participant exposure to a medication that does not work, and is a useful tool in clinical trials. For Alzheimer's disease, where the progression of pathology and clinical measures is ...
COMMENT The TEAM-AD study revives interest in two areas: treatment with antioxidants such as vitamin E, and carrying out clinical trials in patients with mild to moderate AD to evaluate effects on disease progression. The findings of a benefit in the vitamin E ...
COMMENT This study confirms the observation we made years ago that the majority of tau in cerebrospinal fluid (CSF) is not full-length, but consists of fragments that are detectable using N-terminal antibodies. This new study makes use of an extensive panel of ...
COMMENT Several of these awards focus on systems biology approaches, using human or animal model tissue, to identify networks and pathways implicated in Alzheimer's disease. Drs Bennett and De Jager have published several papers illustrating the opportunites ...
COMMENT This is an excellent and carefully conducted study, with implications for extrapolating from transgenic mouse models to human Alzheimer's disease. By characterizing two different transgenic models, one with less-aggressive amyloid pathology, the ...
COMMENT This is an interesting paper. It revisits aspects of standardization of Innogenetics Aβ assays (both ELISA and X-MAP) that have received attention before (e.g., by the Blennow and Shaw laboratories). Previous attempts have defined excellent within ...
COMMENT The editorial makes several important points. Perhaps the most important is that we need a much larger database to understand risks that transform TBI into CTE and its various clinical expressions among people at risk due to sports, war, or other ...
COMMENT These two studies cover different aspects of oxidative stress. The Brewer group showed that wild-type mice as well as 3x transgenic mice developed oxidative changes that could be ameliorated with nicotinamide. The Ho group showed calcium-dependent changes ...
COMMENT This JAMA paper subjects a number of blood-based tests, thought to have diagnostic discrimination in initial publications, to meta-analysis, and found greatly reduced discrimination. Does this mean that current enthusiasm for AD biomarkers should be ...
COMMENT This study is timely in comparing two widely used platforms (ELISA and bead-based multiplex assays [X-MAP]) for measuring cerebrospinal fluid (CSF) analytes related to Alzheimer’s disease. The results support assays for CSF Aβ42 and total tau as being ...
COMMENT This is an excellently written and compelling review, which adds to the drumbeat of support for early intervention or prevention as the design for disease modifying clinical trials in AD. The review is appropriately amyloid-centric, because amyloid has ...
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