81 RESULTS
COMMENT We would like to contribute to the discussion about blood-borne factors entering the brain, with the two STM studies reporting that age-related impairments in the BBB allow for an influx of albumin into the brain, activating TGFβ receptors, overexciting ...
COMMENT Both studies elegantly identify novel interactions between tau and microtubules (MTs) in a physiological setting, either in regulating tau condensation or in protecting MTs from depolymerizing. I have been reminded of a paper from the Safinya lab on the ...
COMMENT We share the view of Drs. Tapias and Beal that misfolded proteins such as Aβ and tau impair all aspects of mitochondrial functions. In fact, we have a long-standing interest in how Aβ and tau impair neuronal functions, dating back to 2005 when we combined ...
COMMENT I really liked this study, which elegantly combines work in human and transgenic tissue, in vitro and in primary cultures. The human brain and doxycycline rescue experiments in rTg4510 mice are especially compelling. I think the question (admittedly a ...
COMMENT This is a very interesting paper. In her news piece Madolyn Rogers writes “It is unclear how the antibodies enter the brain. The authors found no breach of the blood-brain barrier, but did see the antibody accumulate in the choroid plexus of 5xFAD mice, ...
COMMENT It is comforting to see that Bien-Ly and colleagues report on the absence of widespread BBB disruption in AD mouse models and that they further find that the levels of brain infarcts are similar in AD cases and healthy controls. We have recently become ...
COMMENT This is a nice study illustrating the point that assisting in the clearance of Aβ, in addition to preventing its formation, presents a suitable avenue for therapeutic interventions. Together with a study we have published recently (Leinenga and Götz, 2015 ...
COMMENT We are currently doing experiments to address some of the issues that have been raised by Dr. Landreth. There is a wealth of data established in species ranging from rodents to macaques, showing that ultrasound allows for a safe opening of the BBB (some ...
COMMENT I enjoyed reading this paper. The study adds to the notion that a prime function of tau is that of a scaffolding protein, not only in the axon but also in the dendrite where tau interacts, as this study shows, also with filamentous actin. Interesting is ...
COMMENT A very elegant study done in mice, rats, and monkeys showing that clearance of Aβ from the brain is most likely not because of a sink effect between this organ and the periphery. j.goetz 0 ...
COMMENT This is an interesting paper that supports our findings in mouse models and cell lines that soluble tau is toxic, as evidenced by the trapping of the kinesin adapter protein JIP1 in the soma under conditions where tau levels (irrespective of a pathogenic ...
COMMENT An important study emphasising the validity of a tau-based immunotherapeutic approach in AD. j.goetz 0 ...
COMMENT Using state-of-the-art technology, the Mandelkow team presents a very detailed analysis of how Aβ oligomers damage synapses. One of their most interesting findings is that the tau that accumulates in the somatodendritic domain of primary neurons exposed ...
COMMENT This is interesting also in the context of our finding that in the presence of tau the splicing factor SFPQ is relocalized from the nucleus to the cytoplasm. j.goetz 0 Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's ...
COMMENT The identification of PTK2B (also known as Pyk2) is interesting. In our P301L tau mutant pR5 mice, GSK3-Tyr279/216 and AT100-positive neurons selectively display a phosphotyrosine-epitope that is associated with an early activation of Pyk2, suggesting ...
