Satoru Funamoto on Substrate Says—APP Fragments Determine Where γ-Secretase Cuts
COMMENT The most prominent feature of this paper is that C89 is a favored APP substrate cleaved at epsilon 48 by γ-secretase to produce AICD49-99, leading to Aβ42 product line (Takami et al., 2009). It suggests that ectodomain length of substrate influences not ...