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Bess Frost on Tau, Speckle Wrecker, Disrupts the Nuclear Home

COMMENT This lovely study from the Parker lab further implicates tau as a splicing disruptor and identifies RNAs that are sequestered within tau aggregates (Raj et al., 2018; Apicco et al., 2019; Hsieh et al., 2019).  While the mechanistic aspect of the paper ...

Bess Frost on TDP-43 Snarls Nuclear Traffic

COMMENT This paper from the Rossoll group is an important contribution to the emerging concept that disruption of nuclear architecture and nucleocytoplasmic transport are central mediators of neurodegeneration in multiple disorders. The nature of the nuclear ...

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