Brad Friedman on Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and manipulating microglia

COMMENT These look useful and I wouldn’t be surprised if many groups took advantage. The current state of the art for this type of approach is an analogous pair of Cx3cr1-driven mice, which have the drawback, as the authors indicate, of also labeling other non ...

Brad Friedman on TDP-43 Turns Itself Off, Inclusions a False Lead

COMMENT Thank you for this well-written article. I would like to add this recent study, which showed that nucleic acid binding activity is required for TDP-43-mediated toxicity in flies. C-terminal fragments of TDP-43 lack such activity, but are still capable of ...

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Brad Friedman on Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and manipulating microglia

Brad Friedman on TDP-43 Turns Itself Off, Inclusions a False Lead

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