13 RESULTS
COMMENT The contradictions in claims for and against "brain training" arise out of the confusion between symptoms and disease. "Cognitive-enhancement tools" may be effective, for a time, against memory loss and other symptoms of age-related ...
COMMENT It has been known for a long time (references too numerous to cite) that white matter hemorrhages, large or small, may be related to AD pathology via amyloid angiopathy. In fact, the first AD plaque I saw with the electron microscope, back in 1964, I saw ...
COMMENT A most interesting model for AD, but why specifically for the "sporadic" form? Chilean degus manifest "AD" beginning at about three years of age, whereas their "relatives," the Chilean guinea pigs, do not; Calabrian carriers ...
COMMENT Told you so (see reference). I missed from the discussion a mention of the stochastic nature of gene expression, and specifically of the age at onset, as an explanation of the incomplete "penetrance" of mutations with a late expression. ...
COMMENT Was the first step of any genetic investigation, namely the study of the family history of the proband, undertaken in the case of Auguste D. beyond the succinct notes in her clinical record? Her father died aged 45 (no diagnosis given), her mother aged 64 ...
COMMENT "...the NIH needs to make a greater commitment to AD, and if they split AD from the aging institute to do it, so be it." Of course they should. It makes no more sense to look at "aging" processes when doing research on Alzheimer's ...
COMMENT I believe the line "Green algae, also called cyanobacteria" in this story is erroneous. Cyanobacteria, formerly called "blue algae" or "blue-green algae" are prokaryotes and are completely distinct from green algae, which are ...
COMMENT It is not necessary to speculate or postulate that environmental or epigenetic factors that underlie the discordance of AD or LBD expression in monozygotic twins. To explain phenotype variability among genetically identical individuals, stochastic ...
COMMENT Under-reporting of AD in death certificates is an old story, dating back to the time Alzheimer disease was considered a presenile dementia. In our study of early onset familial AD in Italy (1), affected members of the kindred, who generally died in their ...
COMMENT I think that the explanation of microhemorrhages in the brain of vaccinated transgenic mice by the "washing out" of vascular or perivascular amyloid, and the recommendation of early treatment, "before amyloid deposition," is lacking ...
COMMENT What about the concept that AD, instead of being a common disease with a number of "risk factors,” might be a set of numerous rare diseases with a more or less common phenotype, but each with a different cause? That way, there would be no Little ...
COMMENT Of course, as stated in the Kaizer et al. paper, "Aluminum (Al), a neurotoxic agent, has been associated with Alzheimer disease (AD)." Association, however, does not demonstrate causality. Moreover, it is useful to remember that the whole story ...
COMMENT Important as is the paper by Jadaev et al., and going a long way to confirm the genetic etiology of "ordinary" AD as distinct from obviously familial EOAD, one is surprised to find to it, with all those percentages, a "biometrician" ...
