11 RESULTS
COMMENT This is nice intricate work in a model system on the importance of inflammation in clearing amyloid-β (Aβ), as shown indirectly through improvement of clearance by blockade of IL-10. The role of inflammatory activation of macrophages/microglia and ...
COMMENT This article by Lehmann et al. presents interesting results in mice regarding induction of neuronal death by let-7 miRNA through TLR-7 on neurons. They confirmed the results in Tlr7-/- mice, including the Tlr7-/- mice from fetuses transfected by TLR7. ...
COMMENT I wish to join the chorus eulogizing Anne. Though not closely associated with her work, I am still impressed by her accomplishments and the loss suffered by the AD community. Her work on endocytic dysfunction in neurons and fibroblasts and her insights ...
COMMENT We are investigating clearance of intraneuronal amyloid-β in Alzheimer brain sections using incubation (two or four days) with monocytes of control or Alzheimer subjects. Control monocytes intrude into neurons by their processes and upload oligomeric ...
COMMENT I am glad that the researchers studying transgenic models are finally confirming our results published in 2002 (Fiala et al., 2002), which showed transmigration of macrophages across the brain vessel wall and clearance of plaques by these large ...
COMMENT Reply to Frautschy, Teter Comment In response to the comments by Frautschy and others, the objectives of our paper are first to explain the immune mechanisms of amyloidosis in Alzheimer disease patients and second to find out what can be done about ...
COMMENT The results showing increased cardiovascular risk of patients taking COX-2 inhibitors, or a non-selective COX inhibitor, may come as a surprise in the face of extensive research on role of macrophages in atherosclerosis. The results of current animal ...
COMMENT We have noted increased level of intracellular IL-4 and IL-10 in CD4 T cells of patients with AD. We speculate that increased cytokines are compensatory to impaired cellular immunity (Mruthinti et al., 2004). fiala 0 Autoimmunity in Alzheimer's ...
COMMENT The authors should cite the literature on CSF levels of amyloid-β (total and 1-42). Without having a comparison and seeing a discussion of previous CSF studies, I do not know whether the reduced level in CSF is good, bad, or a chance event. Antibodies to ...
COMMENT Akiyama and McGeer describe focal clearance of senile plaques in the cortex of a patient with Alzheimer’s disease in an advanced stage. They interpret this as a result of “microglia and macrophage invasion of the affected area.” Their data are remarkable ...
COMMENT Our published work indicates that (1) COX-2 expression in the AD brain tissues involves blood-derived macrophages, not neurons; (2) macrophages are infiltrating the neuritic plaques and phagocytizing amyloid-beta. COX-2 activation in the brain appears to ...
