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Milan Fiala on Cytokine Takes Aβ Off the Menu for Microglia

COMMENT This is nice intricate work in a model system on the importance of inflammation in clearing amyloid-β (Aβ), as shown indirectly through improvement of clearance by blockade of IL-10. The role of inflammatory activation of macrophages/microglia and ...

Milan Fiala on Safety Concerns Halt ADAPT Trial

COMMENT The results showing increased cardiovascular risk of patients taking COX-2 inhibitors, or a non-selective COX inhibitor, may come as a surprise in the face of extensive research on role of macrophages in atherosclerosis. The results of current animal ...

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