8 RESULTS
COMMENT It is well established that the APOE ε4 allele is associated with higher amyloid plaque levels in Alzheimer’s disease. APOE ε4 may contribute to tau pathology in cortical brain areas mostly via increased levels of amyloid plaques, yet APOE ε4-related incr
COMMENT This is an impressive paper led by Jake Vogel and Oskar Hansson’s group, clearly demonstrating that the spatial patterns of tau pathology are more heterogeneous than commonly thought. In the to-date largest tau-PET sample of 1,612 individuals, they show f
COMMENT This is an elegant study by Kim and colleagues harnessing the gain in statistical power by virtue of focusing on the genetic variants that modify the risk of ApoE e4 genotype based on exome-sequencing data and using the evolutionary-action approach, i.e.,
COMMENT A large body of research has focused on identifying protective lifestyle factors that may enhance cognitive resilience against the effect of primary Alzheimer’s pathology on cognition, but only little is known about those factors that may slow down the de
COMMENT Genetic variants near BIN1 are important risk factors for AD dementia, where the SNP rs744373 is the second most strongly associated genetic locus for sporadic AD after the ApoE ε4 allele. Despite these strong genetic associations of BIN1 with AD dementi
COMMENT We want to clarify an important point. The goal of our study was not to finally determine if sTREM2 or full-length TREM2 exert a protective function, or which variant needs to be therapeutically modified. Rather, we wanted to find out whether TREM2 is pro
COMMENT This study by Richard et al. provides important findings on the diagnostic benefit of combining neuropsychological memory assessment with biomarkers for predicting AD dementia in patients with amnestic MCI. The authors conclude that biomarkers are not use
COMMENT The study by Perrotin et al. shows that subtle decreases in memory and an accompanying awareness of reduced memory performance is associated with higher PIB-PET imaging of β amyloid (Aβ) in the brains of asymptomatic, cognitively normal elders. In view of
