8 RESULTS
COMMENT This study provides new information about a molecular pathogenic mechanism that linked innate immunity activation to increased Aβ production by an interferon-induced transmembrane protein that upregulates γ-secretase activity. Seeing the genetic evidence ...
COMMENT In this carefully performed study, Meyer and colleagues show that in cognitively intact individuals at risk, naproxen does not reduce the progression of presymptomatic AD. The authors conclude that these findings left them with extreme pessimism regarding ...
COMMENT The idea that fungi could be the etiological agent of Alzheimer’s disease (AD) goes back to the earliest years of AD research. In the same year that Alzheimer described the case of Auguste D., Oskar Fischer published his paper about plaque formation. In ...
COMMENT Clinical and epidemiological studies in the elderly have shown that events associated with a low-grade systemic inflammatory response (such as hip surgery and mild urinary infection) can lead to both an acute transient cognitive disturbance (delirium) and ...
COMMENT The reported finding of increased immune gene expression as an early event in transgenic Alzheimer’s disease (AD) mice models is, for several reasons, very intriguing: 1. A major concern—frequently raised in connection with transgenic AD mice models ...
COMMENT Irene Knuesel's hypothesis that late-onset AD might be the result of a two-hit immune challenge is most interesting. Her strategy to develop a wild-type AD animal model is based on a sound scientific background. The genetic evidence for the role of ...
COMMENT It is frequently believed that in brain diseases characterized by a neuroinflammatory response, neurons are passive victims of glia activation by bystander lysis. However, recent findings show that reciprocial interactions between glia and neurons are ...
COMMENT In this study the researchers examined the role of the complement system in murine models of Alzheimer disease (AD). In human AD brains immunohistochemical studies have demonstrated that both early and late complement factors are found in amyloid plaques. ...
