Dieter Edbauer on In New ALS/FTD Mouse Model, Poly(GR) Peptides Poison Ribosomes
COMMENT Zhang et al. report neurodegeneration and behavioral changes in the first poly(GR) mouse model using their AAV-based expression system. Strikingly, these mice show no TDP-43 pathology, suggesting that DPRs also trigger TDP-43-independent pathways of ...