3 RESULTS
COMMENT Zhang et al. report neurodegeneration and behavioral changes in the first poly(GR) mouse model using their AAV-based expression system. Strikingly, these mice show no TDP-43 pathology, suggesting that DPRs also trigger TDP-43-independent pathways of ...
COMMENT Critics will argue that detection of poly-GP in the CSF of presymptomatic C9orf72 carriers by Gendron et al. and us (Lehmer et al., EMBO Mol Med, in press) shows that DPR proteins play no role in C9ORF72 pathogenesis. In contrast, both groups of authors ...
COMMENT To use a sports analogy it's now 3:3—the glycine-alanine camp (May et al., 2014; Zhang YJ et al., 2014; Yamakawa M et al., 2014) and the arginine-rich camp (Kwon I et al., 2014; Mizielinska S et al., 2014; Wen X et al., 2014) are tied. I find the ...
