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Gerard Drewes on MARK Homologue Sparks Tau Terror in Fruit Fly

COMMENT This paper describes an intriguing Drosophila model of tau phosphorylation causing tau neurotoxicity. So far, therapeutic approaches to tau pathology in AD did not progress beyond the preclinical stage and were mainly directed at the inhibition of the ...

Gerard Drewes on BACE Goes Rafting after APP

COMMENT Despite the problems with chemical tractability, β-secretase (BACE) remains one of the most promising targets for the treatment of Alzheimer's disease. It has been known for some time that APP, BACE, and γ-secretase (presenilins and associated ...

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