9 RESULTS
COMMENT The authors demonstrate clear beneficial effects of low concentrations of epothilone D, a brain-permeable microtubule-stabilizing agent, on transgenic mice that develop forebrain tau inclusions. Similar approaches using the marketed cancer drug paclitaxel ...
COMMENT This interesting and technically innovative paper addresses the still enigmatic physiological function of APP. The study sheds new light on APP by comparing its “interactome” (i.e., the sum of its interactions with other proteins) with those of the APP ...
COMMENT Q&A with author. Questions by Gabrielle Strobel. Q: What is the main thrust of the paper? A: It showcases our chemoproteomics technology, which enables the fishing for a drug's targets directly in cells or crude tissue lysate. Because we use ...
COMMENT This paper describes an intriguing Drosophila model of tau phosphorylation causing tau neurotoxicity. So far, therapeutic approaches to tau pathology in AD did not progress beyond the preclinical stage and were mainly directed at the inhibition of the ...
COMMENT Despite the problems with chemical tractability, β-secretase (BACE) remains one of the most promising targets for the treatment of Alzheimer's disease. It has been known for some time that APP, BACE, and γ-secretase (presenilins and associated ...
COMMENT Pen2 is a 101-residue molecule with two predicted transmembrane domains. Topology models predict that the N- and C-termini are cytosolic, which places the small loop between the transmembrane domains in the extracellular side, and this is the way most ...
COMMENT It has only been a few months that APH-1 and PEN-2 were discovered as major players in γ-secretase function in the Notch pathway in C. elegans. Together with recent papers from Haass and Yu, the two present papers demonstrate compelling biochemical ...
COMMENT Lander and colleagues combine data from genomics, transcriptomics, and proteomics, to find the gene causing LDFC, a rare monogenetic disease. In this disease, mitochondrial function is compromised. The emerging candidate gene is (i) one of about 50 genes ...
COMMENT This study demonstrates the power of current state-of-the-art technology in "phosphoproteomics." The authors study the tyrosine phosphorylation events that occur downsteam of T cell activation. They also apply their method to the inhibition of ...
