Gerard Drewes on Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
COMMENT The authors demonstrate clear beneficial effects of low concentrations of epothilone D, a brain-permeable microtubule-stabilizing agent, on transgenic mice that develop forebrain tau inclusions. Similar approaches using the marketed cancer drug paclitaxel ...