4 RESULTS
COMMENT This study by Tong et al. provides the first description of amino acid residues that contribute (or not) to the activation of the homomeric α7 nicotinic acetylcholine receptor (nAChR) by β amyloid (Aβ). Given the mounting evidence that α7 nAChRs and ...
COMMENT In this manuscript, Wang et al. detail an investigation into a presynaptic form of NMDA-independent LTP (mfLTP) at the mossy fiber—CA3 synapse in mice lacking β-secretase (BACE1)—BACE KO. They report that the mfLTP deficits can be rescued by activation of ...
COMMENT In short, Bales et al. provide data suggesting that Aβ association with the choline transporter, ChT-1, leads to augmentation of enzyme activity. In the PDAPP mouse hippocampus, this apparently leads to dysregulation of ACh synthesis and release. ...
COMMENT Nicotine as a pure drug has been demonstrated to be neuroprotective in numerous in-vivo and in-vitro models. In-vitro studies indicate that the α7 subtype of nAChR mediates some types of nicotine-induced neuroprotection in cortical and hippocampal neuron ...
