Rashid Deane on Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis.
COMMENT This is an interesting paper, showing that the concentration of human ApoE, irrespective of the isoforms (ApoE3 or ApoE4), plays a role in determining the extent of brain Aβ accumulation in a mouse model of AD. The authors have tested the effect of human ...