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Bart De Strooper on Field Loses GSM Developer Steven Wagner, 64

COMMENT I am very sad to lose a good colleague and ally in the fight against Alzheimer’s disease. Steve Wagner was the leader in the search for γ-secretase modulators for the treatment of Alzheimer’s, and he generated with his company some very interesting compou

Bart De Strooper on Aducanumab Approval Sparks Backlash

COMMENT The experiments supporting aducanumab were, admittedly, inconclusive regarding its clinical benefit. The FDA points out, however, that the biomarker (amyloid plaques) was convincingly targeted, and this made the FDA believe that the positive clinical effe

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