61 RESULTS
COMMENT Humanized systems are becoming increasingly popular due to their translational potential. However, current in vitro models do not fully recapitulate important features, such as acquisition of mature cell states, three-dimensional structure, or cell-to-cel
COMMENT This is a beautiful paper using spatial transcriptomics to depict the cellular phase of Alzheimer pathology (De Strooper and Karran, 2016). The technology brings us a huge step forward from our transcriptomic paper in 2020 (Chen et al., 2020). With the te
COMMENT risk from the modulators. —Caleb Webber is a co-author of this comment. annerieke.sierksma
COMMENT This is excellent work, and the experiments are very well controlled. The work shows in a convincing way that the APP/SW mutation promotes synaptogenesis and that the increase in Aβ peptide (not the other APP cleavage products) are responsible for this ef
COMMENT It is only a press release, so difficult to say something definitive, BUT this has been the most exciting news of my career. I have always believed that amyloid is a trigger of the disease (Karran et al., 2011) based on all the hard basic research, which
COMMENT It is with deep sadness that I receive this news. Charles was a great scientist and a very kind colleague. We will miss him. Bart.DeStrooper 0
COMMENT This is shocking. I have always been suspicious about the quality of the data supporting the oligomer “soup” hypothesis (see Benilova et al., 2012). It is a pity that this scandal also undermines all the decent work in our field. Aβ undoubtedly plays an
COMMENT These two papers bring the two fields of microglia and of astroglia together, as they reflect a broad discussion among different scientists trying to come to an agreement about the nomenclature in their fields. Clearly, the two papers come to a similar co
COMMENT Our results, and a recent paper from Lee et al. (2022), report a decrease of astrocyte calcium activity at early stages of amyloid pathology. This is in contrast with observations of increased calcium signaling reported in plaque-bearing mice (Kuchibhotla
COMMENT I am very sad to lose a good colleague and ally in the fight against Alzheimer’s disease. Steve Wagner was the leader in the search for γ-secretase modulators for the treatment of Alzheimer’s, and he generated with his company some very interesting compou
COMMENT John was already a giant when I entered the field, and it was so encouraging to meet him in person, being a funny, creative, and friendly man open for a good discussion. John was one of the founders of the field of dementia research and has, together with
COMMENT It is clear that the CMS do not believe that sufficient data are yet available to establish the clinical meaningfulness of aducanumab therapy in Alzheimer’s disease. Thus, their proposed stance is that they will cover aducanumab therapy within the Coverag
COMMENT result indeed provides a strong argument for the use of γ-secretase modulators. We commented a few years
COMMENT The experiments supporting aducanumab were, admittedly, inconclusive regarding its clinical benefit. The FDA points out, however, that the biomarker (amyloid plaques) was convincingly targeted, and this made the FDA believe that the positive clinical effe
COMMENT In this groundbreaking work, Mertens and colleagues compare the transcription profiles in AD and control neurons derived either directly from fibroblasts or from iPSC cells from the same donors. The directly induced neurons maintain epigenetic changes ass
