270 RESULTS
COMMENT I suggest that the E693delta (Osaka) mutation in APP may be pertinent to the SNAP cases (e.g., Tomiyama et al., 2008; Shimada et al., 2011). Paul_Coleman 0 A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia. Clinical ...
COMMENT Of course DNA is not immutable destiny. The results of this study should not have surprised anyone, considering the complexities in the regulation of gene expression. The authors have done a great service by conducting a comprehensive study that ...
COMMENT In 1999, we published a paper titled "Neurons may live for decades with neurofibrillary tangles." The paper was based on the assumption that if one sees many cells exhibiting a defined morphology (in this case, neurons with both nuclei and NFT), ...
COMMENT This is a vitally important paper that provides further evidence for a "silent period" lasting many decades before AD is clinically diagnosed. The authors found abnormally hyperphosphorylated tau in subcortical regions in people between ages ...
COMMENT Can “normative cognitive aging and neurodegenerative disease” be differentiated? In this provocative paper from the Nun study by the outstanding group at Rush, the authors suggest, “These data challenge the concept of normative cognitive aging and suggest ...
COMMENT This paper presents useful information on the effects of postmortem delay on yield and quality of RNA extracted from human brain. The generalization is that long postmortem delay reduces the yield and quality of extracted RNA. Paul_Coleman 0 ...
COMMENT I note with interest the forthcoming Webinar on this topic. I would like to comment that Yan Cao, at Affymetrix, and I did some informal work a few years ago on the number of neurons that were required in order to provide sufficient starting material for ...
COMMENT It seems this study correlates well with the unbiased stereology study of Mark West et al. (see West et al., 1994), which showed age-related loss of neurons in subiculum but not in CA1. In AD, on the other hand, there was age-related loss of neurons in ...
COMMENT I read this news story with sadness. I regret the lack of investigators cooperating on the basis of mutual trust and a handshake. Of course, that is still possible among some, but these days commercial/monetary/legal issues are too often inserted to the ...
COMMENT This is an interesting contribution to knowledge about common properties of cytotoxic amyloid species. Fluorescence of the compound ANS is related to a protein "to which it is bound undergoing transition from unfolded to fully or partially folded ...
COMMENT These CSF data indicating reduced methylation capacity in Alzheimer disease are consistent with our finding of reduced expression of epigenetic marks in AD brain (Mastroeni et al., 2009; Mastroeni et al., in press). It seems noteworthy that the epigenetic ...
COMMENT This finding of a relationship between pesticide exposure and AD is consistent with our study of an identical twin pair discordant for AD in which the AD twin had a history of pesticide exposure, while the non-demented twin had no such history. Paul ...
COMMENT It would be interesting to determine correlations between PIB binding and FDG within each region studied. Assuming that FDG provides a global approximation of synaptic activity, such correlations may provide an indication of the relationship between PIB ...
COMMENT There isn't any further information about this short paper, but there is accumulating evidence for an interaction between ApoE isoform and brain region that caution should be exercised and results not be over-generalized from one brain region to ...
COMMENT The abstract leads one to believe the authors used an ELISA on either single or relatively few neurons captured by LCM? This would be a great technical advance. Paul_Coleman 0 ...
