Christel Claes, Mathew Blurton-Jones on Janus-Faced PLCγ2? Alzheimer’s Risk Protein Toggles TREM2 and TLR Pathways

COMMENT This exciting new study by Andreone et al. examines the importance of PLCy2 activity downstream of TREM2 signaling for survival, myelin phagocytosis, lipid metabolism, and processing of neuronal debris by human microglia. This work also provides an ...

Mathew Blurton-Jones, Christel Claes on Newly Identified Microglia Contain Lipid Droplets, Harm Brain

COMMENT This exciting new study by Marschallinger et al. defines and examines the age-dependent accumulation of lipid droplets within microglia, clearly demonstrating that these lipid-accumulating microglia (LAMs) exhibit a unique transcriptional signature, pro ...

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Christel Claes, Mathew Blurton-Jones on Janus-Faced PLCγ2? Alzheimer’s Risk Protein Toggles TREM2 and TLR Pathways

Mathew Blurton-Jones, Christel Claes on Newly Identified Microglia Contain Lipid Droplets, Harm Brain

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