10 RESULTS
COMMENT This is an excellent summary of recent studies that highlight the importance of vascular disease in the etiology and progression of dementia. These, and other recent studies, add to the growing evidence base suggesting that vascular disease is currently ...
COMMENT This study can also help to dispel the myth that, in older people, higher blood pressure is needed to provide sufficient blood flow to the brain, and that therefore blood pressure lowering may adversely affect cognitive function. It is clear in this study ...
COMMENT The combined methods to assess sleep in this study provide a high-quality snapshot of sleep in this population of essentially cognitively normal or only mildly impaired people. By combining biomarker methods, an equally high-quality phenotyping of ...
COMMENT This is an interesting study, presenting findings in line with our earlier work showing that a single night of sleep deprivation affects cerebrospinal fluid levels of Aβ (Ooms et al., 2014) and with recent work by Yu et al. (2017) indicating that slow ...
COMMENT I have read this pilot study performed by Lucey and colleagues with much interest. It is a carefully performed physiological study that, despite its small sample size, provides exciting new insights in the relationship between sleep and Alzheimer's ...
COMMENT By definition, large studies like these are inherently limited to very simple measurements. In this study, something as physiologically complex as sleep is reduced to participants ticking a single box as part of a larger general questionnaire at two ...
COMMENT David Holtzman and Andrew Lim raise important points for future studies on this topic. Some further thoughts for those who would like to engage in a follow-up study: Despite the overnight stay in a hospital-like environment (clinical research lab) and the ...
COMMENT This study illustrates that considerable progress can be made in Alzheimer's research if we obtain better insight into the normal physiology of Aβ. Researchers and clinicians now use abnormal concentrations of Aβ in CSF to diagnose AD, and even use ...
COMMENT This paper provides in vivo evidence for microvascular changes in AD. j.claassen 0 ...
COMMENT In this paper, we report in vivo evidence of a reduced oxygen supply to the cerebral cortex in AD—a finding that could support the vascular hypothesis for AD. j.claassen 0 ...
