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John Cirrito on When Neurons Get Excited, They Spill α-Synuclein

COMMENT The Yamada paper clearly demonstrates that neuronal activity regulates release of α-synuclein. They use a similar microdialysis system that we have used to show that activity regulates Aβ, and that Dr. Yamada has used to show activity regulates tau. ...

John Cirrito on Endocytosis Pulls α-Secretase From Synapses

COMMENT Marcello and colleagues demonstrate that synaptic activity regulates the levels of ADAM10 on the plasma membrane. Long-term potentiation (LTP) induces ADAM10 internalization by clathrin-mediated endocytosis (CME), whereas LTD induces its insertion into ...

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