16 RESULTS
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COMMENT This is very interesting. I was fascinated by the visual stimulus data a couple years ago, and now the same by the auditory stimulus. This paper goes into a lot of detail to counter the hypothesis that changes in neuronal activity driving a suppression in ...
COMMENT This is an interesting study using incredible resolution to assess localization of Aβ. It supports data from our group and others that a lot of Aβ is made presynaptically. Our in vivo data suggest that 70 percent of Aβ (40 and 42) found in the ...
COMMENT The Yamada paper clearly demonstrates that neuronal activity regulates release of α-synuclein. They use a similar microdialysis system that we have used to show that activity regulates Aβ, and that Dr. Yamada has used to show activity regulates tau. ...
COMMENT This is an interesting series of studies. First, I’ve always thought of the proteasome as a slow processor that degrades a wide variety of things in a cell. That it can act rapidly to modulate neuronal activity is interesting. But more intriguing to me is ...
COMMENT This study by Lawrence et al. on the activity of the N-terminal fragment of Aβ raises some important questions regarding the physiological roles of APP cleavage products. As APP is cleaved, it makes sense that the products could serve as activity ...
COMMENT Clearly, this is an amazing paper. The detail of the number and spatial location of proteins is remarkable. I appreciate their discussion of what the copy number of proteins may mean functionally; to compensate for a relatively small amount of endocytic ...
COMMENT Marcello and colleagues demonstrate that synaptic activity regulates the levels of ADAM10 on the plasma membrane. Long-term potentiation (LTP) induces ADAM10 internalization by clathrin-mediated endocytosis (CME), whereas LTD induces its insertion into ...
COMMENT Iliff and colleagues use a clever approach to describe a brand-new bulk flow clearance pathway for interstitial fluid (ISF) and cerebrospinal fluid (CSF) water as well as molecules; fluids drain through paravenous spaces within parenchyma to be eliminated ...
COMMENT Brouillette and colleagues have developed a system where they can inject synthetic Aβ oligomers into mouse brain, then detect toxicity and accumulation of the exogenous Aβ. There are several instances in the literature of synthetic Aβ being more toxic and ...
COMMENT Whole-cell patch-clamp has been a mainstay neuroscience tool for decades, but is generally only performed in vitro. The few groups that have gotten this to work in vivo have completed near-heroic efforts. While the robot methodology will probably be ...
COMMENT This is an interesting study by Wu and colleagues. Arc appears to mediate PS1 trafficking through the endosomal pathway which increases γ-secretase cleavage of APP and increases Aβ generation. It will be important to determine where and how Arc is ...
COMMENT Dr. Krohn and colleagues have identified another Aβ transporter at the CNS-blood barrier, ABCC1. Interestingly, this particular transporter is highly expressed at the choroid plexus, suggesting that, in addition to playing a role at the blood-brain ...
COMMENT Restituito and colleagues provide interesting and compelling evidence that α-secretase/matrix metalloproteases (MMPs) and γ-secretase lead to a suppression of synaptic activity. NMDA receptors increase enzymatic activity of α-secretase. α-secretase ...
COMMENT This paper by Tampellini and colleagues is an interesting account of amyloid precursor protein (APP) trafficking and amyloid beta (Aβ) metabolism as a result of synaptic activity. Using glycine chemical long-term potentiation (LTP) and direct ...
COMMENT Stress exacerbates many, if not most, diseases. That stress appears to play a role in Alzheimer disease progression is not surprising; however, a molecular mechanism underlying this phenomenon has been lacking. In this paper, Rissman et al. demonstrate a ...
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