11 RESULTS
COMMENT The puzzle of how presenilin (PS) mutations cause familial AD (FAD) is of great importance because, as many believe, it may relate to the origin of sporadic AD. Based on my critical analysis of the research data in comparison with AD features, I deduced a ...
COMMENT A Ca2+ Channel Model for Presenilin (PS) Shen and Kelleher raised a critical question for presenilin (PS) mutations by suggesting a loss-of-function model. I think this model is long overdue. We know most gene mutations cause human diseases by loss of ...
COMMENT Yankner and his colleagues have done an excellent job of showing that aging is a cause of cognitive decline. Although this has been thought for a long time, it has not been directly supported until very recently with the latest technology. The study shows ...
COMMENT Dr. Gandy proposes that estradiol/testosterone activate ERK, so that hormone withdrawal would decrease ERK, a reasonable scheme since many hormone-regulated pathways are reduced in aging. But Aβ is overly produced in the same period and whole world is ...
COMMENT Hormone reduction (gonadal, estrogen, testosterone) is one of the most salient changes in aging (amid energy and growth factor decline, metal imbalance, free radicals, etc.). So it is expected and has been shown to contribute to (though may not be solely ...
COMMENT Reply to Dr. Wong by Ming Chen Many factors are required in brain function, but their roles are not EQUAL. Ca2+ is the only factor that is known today to be both NECESSARY and SUFFICIENT for triggering and controlling neurotransmitter release (any ...
COMMENT Clarification of the confusing terms such as Aβ, βA, APP, βAPP or AβPP will help the field if they can be standardized. But here, I would like to reiterate the key importance of another "nomenclature" problem, i.e., "Alzheimer's ...
COMMENT Reply to Dr. Wong by Ming Chen First, let me take this opportunity to thank Drs. Wong, Scatty and Aldoso for raising in-depth and sharp questions. In science, asking the right questions sometimes can be as important as solving them. The AD field today ...
COMMENT Reply to Dr. Aldoso by Ming Chen In the world of research, we develop hypotheses based on facts. But perhaps the most difficult job is to judge, among the numerous reports, which ones are facts and which are not. Many papers have reported that calcium ...
COMMENT Reply to Dr. Scatty by Ming Chen Conceptualization of Ca2+ signals in the brain as dynamic "spikes" (1-3), instead of traditionally perceived steady-state "level" changes, is essential to explain some key dilemmas that have severely ...
COMMENT Question: Are Alzheimer's Disease and "Senile Dementia" the Same Disease? This perhaps is the most important "nomenclature" problem. AD used to refer to "pre-senile" dementia (PSD; middle age dementia). This name clearly ...
