5 RESULTS
COMMENT This elegant paper provides substantial evidence for a critical role of microglia in building up dense plaques in Aβ overproducing transgenic mice. Though the direct translatability of results obtained using the aggressive APP/PS1-based animal model to ...
COMMENT Linse et al. have published an excellent and elegant biophysical study characterizing the targets and therapeutic mechanisms of four clinical Aβ antibodies. The results provide yet more evidence that disease-modifying activity in AD requires targeting of ...
COMMENT Purro et al. have published an important study. There is much scientific value in this work, but I will focus on the nature of the “proteopathic seeds” that template Aβ amyloidosis, and why this question is critical to human health. Three sobering studies ...
COMMENT This is a very interesting paper, which furthers the concept of "SOD1 strains" in ALS and mouse models of the disease. Infectious prions (CJD in humans, scrapie in sheep, BSE in cattle, and CWD in deer and elk) do not exist in one monolithic ...
COMMENT This is really a remarkable paper, speaking directly to the problem of motor neuron vulnerability in SOD1 familial ALS and mutant SOD1 mouse models. The authors have systematically sought and identified a chaperone activity in non-neuronal cells that ...
