3 RESULTS
COMMENT This paper confirms, in vivo, a role for soluble Aβ oligomers in the disassembly of synapses surrounding plaques. The authors for the first time apply array tomography to quantitatively assess the interaction between postsynaptic densities/spines with ...
COMMENT This paper by the group of Michael Calhoun confirms, in vivo, a role for microglia in amyloid plaque maintenance. The authors succeeded in monitoring live changes in plaque size, and correlate them to changes in number and appearance of “on site” ...
COMMENT This paper is intriguing, to say the least. The authors succeeded in monitoring in vivo the formation of dense-core plaques. Surprisingly, they observed that across different mouse models of Alzheimer disease, plaques formed quite rapidly (24 hours) but ...
