Huaibin Cai on Association Between Early-Onset Parkinson Disease and 22q11.2 Deletion Syndrome: Identification of a Novel Genetic Form of Parkinson Disease and Its Clinical Implications.

COMMENT The authors provide convincing evidence that links chromosome 22q11 deletions to PD. Although patients with 22q11 and LRRK2 mutations share many neuropathological abnormalities, it remains to be determined whether they follow similar pathogenic pathways. ...

Huaibin Cai on Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2).

COMMENT LRRK2 mutations lead to typical Parkinson’s disease and represent a very common cause of both familial and sporadic PD. A variety of studies have been devoted to characterize the pathophysiological functions of LRRK2 and its mutations in order to ...

Huaibin Cai on Double Paper Alert—A Function for BACE, a Basis for Amyloid

COMMENT BACE1 is the principal β-secretase for generation of amyloid-β peptides. Since the identification of BACE1, several lines of BACE1 knockout mice have been made, which are viable and show no major behavioral and pathological abnormalities, suggesting that ...

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Huaibin Cai on Association Between Early-Onset Parkinson Disease and 22q11.2 Deletion Syndrome: Identification of a Novel Genetic Form of Parkinson Disease and Its Clinical Implications.

Huaibin Cai on Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2).

Huaibin Cai on Double Paper Alert—A Function for BACE, a Basis for Amyloid

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