4 RESULTS
COMMENT The interaction of LRRK2 with microtubules is among the earliest observations in the continuous endeavor to understand the biological functions of this large Parkinson's disease related multidomain protein. The memory is still vivid in my mind of our ...
COMMENT The authors provide convincing evidence that links chromosome 22q11 deletions to PD. Although patients with 22q11 and LRRK2 mutations share many neuropathological abnormalities, it remains to be determined whether they follow similar pathogenic pathways. ...
COMMENT LRRK2 mutations lead to typical Parkinson’s disease and represent a very common cause of both familial and sporadic PD. A variety of studies have been devoted to characterize the pathophysiological functions of LRRK2 and its mutations in order to ...
COMMENT BACE1 is the principal β-secretase for generation of amyloid-β peptides. Since the identification of BACE1, several lines of BACE1 knockout mice have been made, which are viable and show no major behavioral and pathological abnormalities, suggesting that ...
