4 RESULTS
COMMENT This paper suggests that defects in GLT-1 (also known as EAAT2) in astrocytes lead to accumulation of synaptic glutamate, which causes hyperactivity, leading to excitotoxicity of and Ca2+ entry to neurons. Nearly two decades ago, our laboratory ...
COMMENT The interesting paper by Bart De Strooper and colleagues (1) points to nitrosative modification of the γ-secretase complex in aged neuronal cultures with consequent elevated Aβ(1-42) formation. The authors opine that aging, the major risk factor for ...
COMMENT The interesting paper by Fernandez et al. (2009) reports that elevated cholesterol lowers brain mitochondrial glutathione (GSH), which, in turn, leads to increased oxidative vulnerability of mitochondria by Aβ42 in ex vivo experiments. In addition, the ...
COMMENT This paper elegantly demonstrates that the peptidyl prolyl isomerase Pin1 regulates amyloid-β production via binding to Thr668Pro of amyloid precursor protein (APP). Pin 1 binds to phosphorylated Ser/Thr-Pro motifs in proteins to regulate numerous ...
