Bruno Bulic on Novel γ-secretase enzyme modulators directly target presenilin protein.

COMMENT Comment by Sascha Weggen, Thorsten Jumpertz, Andreas Rennhack, Bruno Bulic Despite substantial progress in the chemical and preclinical development of γ-secretase modulators (GSMs), the molecular mechanism and target of GSMs have remained controversial. ...

Bruno Bulic on Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein.

COMMENT Strong evidence has been provided that γ-secretase modulators (GSMs) directly affect enzyme activity by the demonstration that GSMs selectively lower Aβ42 production and increase shorter Aβ species in cell-free γ-secretase assays (Takahashi et al., 2003; ...

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Bruno Bulic on Novel γ-secretase enzyme modulators directly target presenilin protein.

Bruno Bulic on Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein.

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