6 RESULTS
COMMENT These two papers support each other, and, coming from two different teams and using different approaches, that is clearly a great strength. When it comes to neuropathology and genetic risk, the lines between AD, DLB, and PD (especially PDD) are becoming ...
COMMENT I have received conference/lecture honorariums from Prothena and have been a scientific consultant to Roche. This year represents the 10th anniversary of the birth of the concept of prion-like propagation of α-synuclein pathology, and it is gratifying to ...
COMMENT The study by Mao and collaborators is extremely interesting. It addresses the issue of whether specific mechanisms govern neuronal uptake of α-synuclein fibrils from the extracellular space. The demonstrations that lymphocyte-activation gene 3 (LAG3) ...
COMMENT Freer and collaborators’ findings are very interesting indeed. The notion that there are differences between brain regions regarding their “permissiveness” to protein misfolding disease has been discussed for decades, but strong supporting data have been ...
COMMENT The investigators have identified a novel pathway that is active during secretion of misfolded α-synuclein to the extracellular space. These are very exciting findings that potentially will impact research into novel therapeutic targets for Parkinson¹s ...
COMMENT These results are very exciting indeed. Not only did the authors observe the spread of α-synuclein in areas distal to the injection sites, but they also found the most severe pathology in areas exhibiting dense interconnections. These observations support ...
