8 RESULTS
COMMENT Although mostly studied in neurons, Presenilin1 (encoding for PS1) is broadly expressed in the immune system, including microglia. The authors of this interesting work suggest that PS1 is an important regulator of the lysosomal machinery in microglia. The ...
COMMENT The group of Jaime Grutzendler has recently developed a cutting-edge technique, 2Phatal, allowing researchers to induce apoptosis of individual neuronal cells using a photochemical reaction. From the same group, Damisah and colleagues now took advantage ...
COMMENT Alzheimer’s disease is characterized by extracellular deposition of Aβ and intraneuronal accumulation of hyperphosphorylated tau protein. Previous studies showed that dementia correlates well with tau, but not with Aβ burden, indicating that tau ...
COMMENT This latest work from Kim Green’s laboratory shows that prolonged microglia depletion in 5xFAD mice (a common mouse model for AD) greatly reduces plaque formation, thus confirming recent findings by another group (Sosna et al., 2018). Notably, this ...
COMMENT Recent evidence showed that, during aging, microglia accumulate lipids within the phagosomes. Hence, it has been suggested that lipid-rich microglia would less efficiently uptake and degrade cellular debris or protein aggregates, and this may contribute ...
COMMENT Some research groups were recently able to generate a surrogate of human microglia using induced-pluripotent stem cells (iPSC) derived from human fibroblasts (Muffat et al., 2016; Abud et al., 2017; Pandya et al., 2017; Takata et al., 2017). These studies ...
COMMENT Mouse models for Alzheimer’s disease only partially recapitulate the complexity of the human disease. Indeed, despite their aggressive amyloid pathology, current mouse models develop neither neurofibrillary tangles nor neuronal loss, both major hallmarks ...
COMMENT Pluvinage et al. elucidate previously unappreciated roles for CD22 in the aging brain. Comparing young and old mice, the group of Tony Wyss-Coray observed that CD22 is increased in microglia during aging. This observation was rather unexpected as CD22 is ...
